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[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Stadtman E.R

Bartlett, H

This triple mechanism of action is designed to promote significant reductions in body weight and improve metabolic parameters

3.2 Therapeutic potential via paracrine mechanisms The therapeutic effects of MSCs are primarily mediated through their paracrine activity, which involves the secretion of bioactive factorssuch as growth factors, chemokines, cytokines, and EVsto modulate the local microenvironment (Pittenger et al., 2019

36 Moreover, GLP-1 RAs improve lipid profiles by decreasing serum cholesterol and triglyceride levels and increasing high-density lipoprotein (HDL) levels contributing to cardiovascular protection